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KMID : 0363620130340010089
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Journal of Korean Oriental Medicine
2013 Volume.34 No. 1 p.89 ~ p.102
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Effects of Root of Curcumin longa on LPS-induced Lung Injury
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Oh Ji-Seok
Yang Soo-Young
Kim Min-Hee
Namgung Uk
Park Yang-Chun
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Abstract
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Objectives: This study aimed to evaluate the effects of root of Curcumin longa (RCL) on LPS-induced COPD (chronic obstructive pulmonary disease) model.
Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then, various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and histopathological finding were analyzed.
Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue.
Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific evidence for the efficacy of RCL for clinical application to COPD patients.
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KEYWORD
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Root of Curcumin longa, chronic obstructive pulmonary disease, emphysema, RAW 264.7 cells
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